2113 Viewed775 Downloaded
Evaluation of Prognostic Nutritional Status in Late-onset Fetal Growth Restriction
Received: 07 Oct 2020 | Received in revised form: 18 Feb 2021
Accepted: 11 Mar 2021 | Available online: 18 Mar 2021Ersin ÇİNTESUNa, Elif IŞIKa, Çetin ÇELİKa, Özlem SEÇİLMİŞ KERİMOĞLU a
aDepartment of Obstetrics and Gynecology, Selçuk University Faculty of Medicine, Konya, TURKEY
J Clin Obstet Gynecol. 2021;31(1):14-9
DOI: 10.5336/jcog.2020-79476
Article Language: TR
Copyright Ⓒ 2024 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (
http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
Objective: We aimed to investigate the relationship between Onodera's prognostic nutrition index (OPNI) and controlling nutritional status index (CONUT) that are used for evaluating the nutritional status and late-onset fetal growth restriction (FGR). Material and Methods: This study was a prospective cross-sectional study on 141 patients, which was conducted at the Medical Faculty of Selcuk University. The study included 62 women with late-onset FGR and 79 control patients. The control group was randomly selected from among pregnant women in the 32nd-37th gestational weeks with pre-pregnancy body mass index (BMI) 0.05). Before birth and pre-pregnancy weight, height, and pre-pregnancy BMI were significantly different between the groups (p0.05). We classified the CONUT score calculation according to two different cut-off values, and both classifications were similar between the groups (p>0.05). Conclusion: It has been shown that the OPNI and CONUT scores, which are used to predict nutritional status and prognosis in cancer and chronic diseases, are not useful to predict the late-onset FGR.
REFERENCES:- Nardozza LM, Caetano AC, Zamarian AC, Mazzola JB, Silva CP, Marçal VM, et al. Fetal growth restriction: current knowledge. Arch Gynecol Obstet. 2017;295(5):1061-77. [Crossref] [PubMed]
- International Stillbirth Alliance Collaborative for Improving Classification of Perinatal Deaths, Flenady V, Wojcieszek AM, Ellwood D, Leisher SH, Erwich JJHM, Draper ES, et al. Classification of causes and associated conditions for stillbirths and neonatal deaths. Semin Fetal Neonatal Med. 2017;22(3):176-85. [Crossref] [PubMed]
- Miller SL, Huppi PS, Mallard C. The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome. J Physiol. 2016;594(4):807-23. [Crossref] [PubMed] [PMC]
- Francis JH, Permezel M, Davey MA. Perinatal mortality by birthweight centile. Aust N Z J Obstet Gynaecol. 2014;54(4):354-9. [Crossref] [PubMed]
- Shah PS; Knowledge Synthesis Group on Determinants of LBW/PT births. Parity and low birth weight and preterm birth: a systematic review and meta-analyses. Acta Obstet Gynecol Scand. 2010;89(7):862-75. [Crossref] [PubMed]
- Odibo AO, Nelson D, Stamilio DM, Sehdev HM, Macones GA. Advanced maternal age is an independent risk factor for intrauterine growth restriction. Am J Perinatol. 2006;23(5):325-8. [Crossref] [PubMed]
- Han Z, Mulla S, Beyene J, Liao G, McDonald SD; Knowledge Synthesis Group. Maternal underweight and the risk of preterm birth and low birth weight: a systematic review and meta-analyses. Int J Epidemiol. 2011;40(1):65-101. [Crossref] [PubMed]
- Jaddoe VW, Bakker R, Hofman A, Mackenbach JP, Moll HA, Steegers EA, et al. Moderate alcohol consumption during pregnancy and the risk of low birth weight and preterm birth. The generation R study. Ann Epidemiol. 2007;17(10):834-40. [Crossref] [PubMed]
- Villar J, Papageorghiou AT, Pang R, Ohuma EO, Cheikh Ismail L, Barros FC, et al; International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st). The likeness of fetal growth and newborn size across non-isolated populations in the INTERGROWTH-21st Project: the Fetal Growth Longitudinal Study and Newborn Cross-Sectional Study. Lancet Diabetes Endocrinol. 2014;2(10):781-92. [Crossref] [PubMed]
- ACOG Practice bulletin no. 134: fetal growth restriction. Obstet Gynecol. 2013;121(5):1122-33. [Crossref] [PubMed]
- Baschat AA. Neurodevelopment following fetal growth restriction and its relationship with antepartum parameters of placental dysfunction. Ultrasound Obstet Gynecol. 2011;37(5):501-14. [Crossref] [PubMed]
- Figueras F, Gratacos E. An integrated approach to fetal growth restriction. Best Pract Res Clin Obstet Gynaecol. 2017;38:48-58. [Crossref] [PubMed]
- Savchev S, Figueras F, Sanz-Cortes M, Cruz-Lemini M, Triunfo S, Botet F, et al. Evaluation of an optimal gestational age cut-off for the definition of early-and late-onset fetal growth restriction. Fetal Diagn Ther. 2014;36(2):99-105. [Crossref] [PubMed]
- Crispi F, Llurba E, Domínguez C, Martín-Gallán P, Cabero L, Gratacós E. Predictive value of angiogenic factors and uterine artery Doppler for early- versus late-onset pre-eclampsia and intrauterine growth restriction. Ultrasound Obstet Gynecol. 2008;31(3):303-9. [Crossref] [PubMed]
- Hu Y, Shen J, Liu R, Feng Z, Zhang C, Ling L, et al. Prognostic value of pretreatment prognostic nutritional index in non-small cell lung cancer: A systematic review and meta-analysis. Int J Biol Markers. 2018;33(4):372-8. [Crossref] [PubMed]
- Tsai MT, Chang TH, Wu BJ. Prognostic impact of nutritional risk assessment in patients with chronic schizophrenia. Schizophr Res. 2018;192:137-41. [Crossref] [PubMed]
- Kang SH, Cho KH, Park JW, Yoon KW, Do JY. Onodera's prognostic nutritional index as a risk factor for mortality in peritoneal dialysis patients. J Korean Med Sci. 2012;27(11):1354-8. [Crossref] [PubMed] [PMC]
- Kuroda D, Sawayama H, Kurashige J, Iwatsuki M, Eto T, Tokunaga R, et al. Controlling Nutritional Status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection. Gastric Cancer. 2018;21(2):204-12. [Crossref] [PubMed]
- Yamamoto M, Saito H, Uejima C, Tanio A, Tada Y, Matsunaga T, et al. Prognostic Value of Combined Tumor Marker and Controlling Nutritional Status (CONUT) Score in Colorectal Cancer Patients. Yonago Acta Med. 2019;62(1):124-30. [Crossref] [PubMed] [PMC]
- Li Y, Zhang C, Ji R, Lu H, Zhang W, Li LL, et al. Prognostic significance of the controlling nutritional status (CONUT) score in epithelial ovarian cancer. Int J Gynecol Cancer. 2020;30(1):74-82. [Crossref] [PubMed]
- Onodera T, Goseki N, Kosaki G. [Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients]. Nihon Geka Gakkai Zasshi. 1984;85(9):1001-5. [PubMed]
- Go SI, Jeon H, Park SW, Kang MH, Kim HG, Lee GW. Low pre-treatment nutritional index is significantly related to poor outcomes in small cell lung cancer. Thorac Cancer. 2018;9(11):1483-91. [Crossref] [PubMed] [PMC]
- Ikeya T, Shibutani M, Maeda K, Sugano K, Nagahara H, Ohtani H, et al. Maintenance of the nutritional prognostic index predicts survival in patients with unresectable metastatic colorectal cancer. J Cancer Res Clin Oncol. 2015;141(2):307-13. [Crossref] [PubMed]
- Desyibelew HD, Dadi AF. Burden and determinants of malnutrition among pregnant women in Africa: A systematic review and meta-analysis. PLoS One. 2019;14(9):e0221712. [Crossref] [PubMed] [PMC]
- Belkacemi L, Nelson DM, Desai M, Ross MG. Maternal undernutrition influences placental-fetal development. Biol Reprod. 2010;83(3):325-31. [Crossref] [PubMed]
- Roberts CT, Sohlstrom A, Kind KL, Earl RA, Khong TY, Robinson JS, et al. Maternal food restriction reduces the exchange surface area and increases the barrier thickness of the placenta in the guinea-pig. Placenta. 2001;22(2-3):177-85. [Crossref] [PubMed]
- Lumey LH. Compensatory placental growth after restricted maternal nutrition in early pregnancy. Placenta. 1998;19(1):105-11. [Crossref] [PubMed]
- Hsu CN, Tain YL. The Good, the Bad, and the Ugly of Pregnancy Nutrients and Developmental Programming of Adult Disease. Nutrients. 2019;11(4):894. [Crossref] [PubMed] [PMC]
- Ferdous F, Rashid MH, Ma E, Raqib R, Hamada H, Wagatsuma Y. Fetal growth restriction in rural Bangladesh: a prospective study. Trop Med Health. 2018;46:3. [Crossref] [PubMed] [PMC]
- Sargent IL, Redman CW. Maternal cell-mediated immunity to the fetus in human pregnancy. J Reprod Immunol. 1985;7(2):95-104. [Crossref] [PubMed]
- Kühnert M, Strohmeier R, Stegmüller M, Halberstadt E. Changes in lymphocyte subsets during normal pregnancy. Eur J Obstet Gynecol Reprod Biol. 1998;76(2):147-51. [Crossref] [PubMed]
- Mendenhall HW. Serum protein concentrations in pregnancy. I. Concentrations in maternal serum. Am J Obstet Gynecol. 1970;106(3):388-99. [Crossref] [PubMed]
- Herrera E, Ortega-Senovilla H. Lipid metabolism during pregnancy and its implications for fetal growth. Curr Pharm Biotechnol. 2014;15(1):24-31. [Crossref] [PubMed]
- Lippi G, Albiero A, Montagnana M, Salvagno GL, Scevarolli S, Franchi M, et al. Lipid and lipoprotein profile in physiological pregnancy. Clin Lab. 2007;53(3-4):173-7. [PubMed]
- Iseki Y, Shibutani M, Maeda K, Nagahara H, Ohtani H, Sugano K, et al. Impact of the Preoperative Controlling Nutritional Status (CONUT) score on the survival after curative surgery for colorectal cancer. PLoS One. 2015;10(7):e0132488. [Crossref] [PubMed] [PMC]