E-ISSN: 2619-9467

Contents    Cover    Publication Date: 08 Jul 2021
Year 2021 - Volume 31 - Issue 2

Open Access

Peer Reviewed

ORIGINAL RESEARCH
375 Viewed67 Downloaded

A Retrospective Analysis of Clinical Features, Maternal and Neonatal Outcomes of COVID-19 patients in an Obstetric Clinic in Ankara, Turkey

Full Text PDF  
J Clin Obstet Gynecol. 2021;31(2):72-6
DOI: 10.5336/jcog.2021-82263
Article Language: EN
Copyright Ⓒ 2020 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
Objective: To evaluate the effects of coronavirus disease-2019 (COVID-19) infection on clinical and laboratory features; maternal and fetal outcomes. Material and Methods: In this retrospective study, the patients diagnosed with COVID-19 by positive severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) reverse transcription polymerase chain reaction (RT-PCR) and delivered at Koru Hospital (Ankara, Turkey) between March 2020 and February 2021 were included. We obtained demographic, clinical, laboratory features, obstetric and delivery history, maternal and perinatal outcomes from medical records. Results: Twelve pregnant patients were included in the study. The mean age was 32 years (range 28-43 years) and the mean gestational age at diagnosis of COVID-19 was 34 weeks (range 22 to 39 weeks 6 days), the mean gestational age at delivery was 38 weeks 4 days (range 35 to 40 weeks). All deliveries were as cesarean section. At first admission with suspicion of COVID-19, seven (58%) patients had fever, five (41%) patients had cough, two (16%) patients had dyspnea, two (16%) patients had anosmia and loss of taste, one (8.3%) patient had sore throat. None of the pregnant patients were taken to the intensive care unit before or after delivery. One neonate was tested for SARS-CoV-2 RT-PCR and the result was negative. Two neonates were admitted to neonatal intensive care unit due to preterm delivery of a twin pregnancy. Conclusion: COVID-19 infection has similar clinical characteristics in pregnant patients as in non-pregnants reported in the literature. The maternal, fetal and neonatal outcomes were good and vertical transmission seems unlikely.
REFERENCES:
  1. Narang K, Enninga EAL, Gunaratne MDSK, Ibirogba ER, Trad ATA, Elrefaei A, et al. SARS-CoV-2 infection and COVID-19 during pregnancy: a multidisciplinary review. Mayo Clin Proc. 2020;95(8):1750-65. [Crossref]  [PubMed]  [PMC] 
  2. Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect Dis. 2020;20(5):559-64. [Crossref]  [PubMed]  [PMC] 
  3. Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Coronavirus disease 2019 (COVID-19) and pregnancy: what obstetricians need to know. Am J Obstet Gynecol. 2020;222(5):415-26. [Crossref]  [PubMed]  [PMC] 
  4. Kronborg TM, Kimer N, Junker AE, Werge MP, Gluud LL, Ytting H. Experience from a COVID-19 first-line referral clinic in Greater Copenhagen. Dan Med J. 2020;7;67(9):A05200343. [PubMed] 
  5. Thachil J, Tang N, Gando S, Falanga A, Cattaneo M, Levi M, et al. ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost. 2020;18(5):1023-6. [Crossref]  [PubMed] 
  6. Dashraath P, Wong JLJ, Lim MXK, Lim LM, Li S, Biswas A, et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol. 2020;222(6):521-31. [PubMed]  [PMC] 
  7. Dong L, Tian J, He S, Zhu C, Wang J, Liu C, et al. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA. 2020;12;323(18):1846-8. [Crossref]  [PubMed]  [PMC] 
  8. Zeng H, Xu C, Fan J, Tang Y, Deng Q, Zhang W, et al. Antibodies in infants born to mothers with COVID-19 pneumonia. JAMA. 2020;12; 323(18):1848-9. [Crossref]  [PubMed]  [PMC] 
  9. Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;7;395(10226):809-15. Erratum in: Lancet. 2020;28;395(10229):1038. [Crossref]  [PubMed]  [PMC] 
  10. Alzamora MC, Paredes T, Caceres D, Webb CM, Valdez LM, La Rosa M. Severe COVID-19 during pregnancy and possible vertical transmission. Am J Perinatol. 2020;37(8):861-5. [Crossref]  [PubMed]  [PMC] 
  11. Elshafeey F, Magdi R, Hindi N, Elshebiny M, Farrag N, Mahdy S, et al. A systematic scoping review of COVID-19 during pregnancy and childbirth. Int J Gynaecol Obstet. 2020;150(1): 47-52. [Crossref]  [PubMed]