E-ISSN: 2619-9467

Contents    Cover    Publication Date: 22 Jun 2022
Year 2022 - Volume 32 - Issue 2

Open Access

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SCIENTIFIC LETTER
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Anti-Thyroid Peroxidase Antibody and Hypothyroidism in Recurrent Pregnancy Miscarriage
Received: 18 Oct 2021 | Received in revised form: 23 Mar 2022
Accepted: 12 May 2022 | Available online: 24 May 2022
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Mayada Khalil ALIa, Nuha Mohammed OSMANb, Nafisa Hassan GADOc, Omer Mustafa MOHAMMEDd, Ebtehal Mohamed FAWZIb, Shiema Abdelmagid ELBASHEERe, Alaa Ali ELHUSSEINf , Ahmed Omer ABOELHASSANb, Abdelmonem Mohammed ALIb, Alfatih Aboalbasher YOUSIFg, Nagia Suliman AHMEDh
aDepartment of Medical Microbiology, College of Medical Laboratory Science, Gezira University, Sudan
bDepartment of Clinical Chemistry, College of Medical Laboratory Science, AL-Neelain University, Sudan
cDepartment of Clinical Chemistry , Chemistry, College of Medical Laboratory Science, University of El imam El Mahdi, Sudan
dDepartment of Histopathology and Cytology, College of Medical Laboratory Science, University of Medical Sciences and Technology (UMST), Sudan
eDepartment of Microbiology, College of Medical Laboratory Science, University of Alzaiem Al Azhari, Sudan
fDepartment of Hematology and Immunohematology, Sudan University of Science and Technology, Sudan
gDepartment of Hematology and Immunohematology, College of Medical Laboratory Science, University of Alzaiem Al Azhari, Sudan
hDepartment of Clinical Chemistry, College of Medical Laboratory Science, University of Gezira, Sudan
JCOG. 2022;32(2):67-71
DOI: 10.5336/jcog.2021-86703
Article Language: EN
Copyright Ⓒ 2020 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
 Thyroid disorders are one of the endocrine diseases that may develop during pregnancy. Thyroid autoimmunity (TAI) is commonly prevalent among these diseases in women of childbearing age. TAI includes thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies, and thyrotropin receptor antibodies. However, TPOAb is the most common antithyroid autoantibodies observed in women with recurrent miscarriage (RM) history. Although the precise mechanisms of the TPOAb's role in RM are not fully understood, multiple studies have found that the presence of TPOAb at a high level may increase the risk of recurrent pregnancy loss. The literature in this article was conducted based on published databases in PubMed, Web of Science, Google Scholar, and some international organizations It aims to emphasize the importance of screening for TPOAb in women with RM. It concludes that, according to published studies, the TPOAb could be considered as a good indicator of women at risk of RM.
KEYWORDS: Abortion; antibodies; hypothyroidism; iodide peroxidase; pregnancy; thyroiditis
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