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Year 1996 - Volume 6 - Issue 4

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The Comparison Of Oral Clindamycin And Metronidazole In The Treatment Of Bacterial Vaginosis
Bakteriyal Vajinozis Tedavisinde Oral Klindamisin ve Metronidazol Karşılaştırılması

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Turkiye Klinikleri J Gynecol Obst. 1996;6(4):321-4

Article Language: TR
Copyright Ⓒ 2020 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ÖZET
Amaç: Bakteriyal vajinozis tedavisinde oral klindamisin etkinliğinin metronidazol ile karşılaştırılması. Çalışmanını Yapıldığı Yer: Karadeniz Teknik Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum AD, Trabzon. Materyel ve Metod: Klinik tanı ve Gram boyama kriterlerine göre Bakteriyal Vajinozis tespit edilen toplam 65 hastaya oral klindamisin veya metronidazol verildi. Olgular tedaviden 15 gün sonra kontrole çağrıldı. Bulgular: Klindamisin grubunda %78 (25/32), Metronidazol grubunda %82 (27/33) iyileşme tespit edildi (p> 0.05). Yan etkiler hafifti. Klindamisin grubunda yumuşak gaita, Metronidazol grubunda gastrointestinal rahatsızlık şikayeti daha fazla görüldü. Sonuç: Oral klindamisin Bakteriyal Vajinozis tedavisinde metronidazol kadar etkilidir. Bakteriyal vajinozis tedavisinde önerilen dozlarda yan etki azdır.
ABSTRACT
Objective: To compare the efficacy of oral clindamycin and metronidazole for the treatment of bacterial vaginosis. Institution: Karadeniz Technical University, the Faculty of Medicine, Department of Obstetric and Gynecology, Trabzon. Material and Methods: According to their clinical examinations and Gram stain criteria, sixty-five women with bacterial vaginosis were assigned to receive either oral clindamycin or metronidazole for the treatment of bacterial vaginosis. The patients were seen for follow-up at 15 days after completion of therapy. Results: The cure rate at 15 days after therapy was 78% (25/32) in the clindamycin group versus 82% (27/33) in the metronidazole group (p> 0.05) Adverse reactions were mild, though more patients receiving metronidazole complained of gastrointestinal upset, and loose stool was more common in the oral clindamycin group. Conclusions: Oral clindamycin is as effective for the treatment of bacterial vaginosis as metronidazole, and adverse reactions are mild in the doses of the treatment of bacterial vaginosis.