E-ISSN: 2619-9467

Contents    Cover    Publication Date: 25 Jun 2019
Year 2019 - Volume 29 - Issue 2

Open Access

Peer Reviewed

1861 Viewed1097 Downloaded

Effect of Short Term Supplementation of Coenzyme Q10 on Cumulative Pregnancy Rates in Young InfertileWomen with Polycystic Ovarian Syndrome

Full Text PDF  
J Clin Obstet Gynecol. 2019;29(2):62-7
DOI: 10.5336/jcog.2019-66096
Article Language: EN
Copyright Ⓒ 2020 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Objective: To investigate the effect of coenzyme Q10 (CoQ10) supplementation on ovulation induction (OI) and intrauterine insemination (IUI) outcomes in polycystic ovary syndrome (PCOS) patients with clomiphene citrate (CC) failure or resistance. Material and Methods: A total of 130 nulliparous infertile patients diagnosed with PCOS were included in this prospective study. The first group of patients who were unable to conceive after the first treatment with CC received CoQ10 treatment at a dosage of 100 mg/bid for one month (study group). The other group (control group) received no treatment with CoQ10. The two groups were compared with each other in terms of cycle characteristics and success of the treatment for the subsequent three months. Results: The study group included 66 patients and the control group involved 64 patients. No statistically significant differences were observed between the groups in terms of age, body mass index (BMI), and infertility type. All the study participants had previously received similar medical treatments for infertility. Duration of infertility was significantly longer in the study group as compared to that in the control group (3.4 ±1.5 vs. 2.9 ±1.1 years). Cumulative pregnancy rates were observed to be 18 (27.3%) and 21 (32.8%) in the study and control group, respectively. Conclusion: Short term CoQ10 supplementation was not found to be an effective adjuvant therapy for cumulative pregnancy rates in young infertile women with PCOS who have undergone ovulation induction with intrauterine insemination. Yet, this treatment may prove to be effective on some other subgroup of women.
  1. Asunción M, Calvo RM, San Millán JL, Sancho J, Avila S, Escobar-Morreale HF. A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J Clin Endocrinol Metab. 2000;85(7):2434-8. [Crossref] [PubMed]
  2. Hull MG. Epidemiology of infertility and polycystic ovary disease: endocrinological and demographic studies. Gynecol Endocrinol. 1987;1(3):235-45. [Crossref] [PubMed]
  3. May-Panloup P, Chretien MF, Malthiery Y, Reynier P. Mitochondrial DNA in the oocyte and the developing embryo. Curr Top Dev Biol. 2007;77:51-83. [Crossref]
  4. Digiesi V, Cantini F, Oradei A, Bisi G, Guarino GC, Brocchi A, et al. Coenzyme Q10 in essential hypertension. Mol Aspects Med. 1994;15 Suppl:S257-63. [Crossref]
  5. Kolahdouz Mohammadi R, HosseinzadehAttar MJ, Eshraghian MR, Nakhjavani M, Khorami E, Esteghamati A. The effect of coenzyme Q10 supplementation on metabolic status of type 2 diabetic patients. Minerva Gastroenterol Dietol. 2013;59(2):231 6.
  6. Lee BJ, Yen CH, Hsu HC, Lin JY, Hsia S, Lin PT. A significant correlation between the plasma levels of coenzyme Q10 and vitamin B-6 and a reduced risk of coronary artery disease. Nutr Res. 2012;32(10):751-6. [Crossref] [PubMed]
  7. Bentov Y, Esfandiari N, Burstein E, Casper RF. The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients. Fertil Steril. 2010;93(1):271-5. [Crossref] [PubMed]
  8. Xu Y, Nisenblat V, Lu C, Li R, Qiao J, Zhen X, et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reprod Biol Endocrinol. 2018;16(1):29. [Crossref] [PubMed] [PMC]
  9. Amin MM, Asaad GF, Abdel Salam RM, El-Abhar HS, Arbid MS. Novel CoQ10 antidiabetic mechanisms underlie its positive effect: modulation of insulin and adiponectine receptors, Tyrosine kinase, PI3K, glucose transporters, sRAGE and visfatin in insulin resistant/diabetic rats. PLoS One. 2014;9(2): e89169. [Crossref] [PubMed] [PMC]
  10. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015;40(4):413-8. [Crossref] [PubMed]
  11. The Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1):19-25. [Crossref]
  12. Westphal LM, Polan ML, Trant AS. Doubleblind, placebo-controlled study of fertility blend: a nutritional supplement for improving fertility in women. Clin Exp Obstet Gynecol. 2006;33(4):205-8.
  13. Brough L, Rees GA, Crawford MA, Morton RH, Dorman EK. Effect of multiple-micronutrient supplementation on maternal nutrient status, infant birth weight and gestational age at birth in a low-income, multi-ethnic population. Br J Nutr. 2010;104(3):437-45. [Crossref] [PubMed]
  14. Bedwal RS, Bahuguna A. Zinc, copper and selenium in reproduction. Experientia. 1994;50(7):626-40. [Crossref]
  15. Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Use of multivitamins, intake of B vitamins, and risk of ovulatory infertility. Fertil Steril. 2008;89(3):668-76. [Crossref] [PubMed] [PMC]
  16. Lim SS, Noakes M, Norman RJ. Dietary effects on fertility treatment and pregnancy outcomes. Curr Opin Endocrinol Diabetes Obes. 2007;14(6):465-9. [Crossref] [PubMed]
  17. Mier-Cabrera J, Genera-García M, De la JaraDíaz J, Perichart-Perera O, Vadillo-Ortega F, Hernandez-Guerrero C. Effect of vitamins C and E supplementation on peripheral oxidative stress markers and pregnancy rate in women with endometriosis. Int J Gynaecol Obstet. 2008;100(3):252-6. [Crossref] [PubMed]
  18. Ebisch IM, Thomas CM, Peters WH, Braat DD, Steegers-Theunissen RP. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum Reprod Update. 2007;13(2):163-74.[Crossref] [PubMed]
  19. Cummins JM. The role of mitochondria in the establishment of oocyte functional competence. Eur J Obstet Gynecol Reprod Biol. 2004;115 Suppl 1:S23-9. [Crossref] [PubMed]
  20. May-Panloup P, Chretien MF, Malthiery Y, Reynier P. Mitochondrial DNA in the oocyte and the developing embryo. Curr Top Dev Biol. 2007;77:51-83. [Crossref]
  21. Victor VM, Rocha M, Bañuls C, Sanchez-Serrano M, Sola E, Gomez M, et al. Mitochondrial complex I impairment in leukocytes from polycystic ovary syndrome patients with insulin resistance. J Clin Endocrinol Metab. 2009;94(9):3505-12. [Crossref] [PubMed]
  22. Luce K, Weil AC, Osiewacz HD. Mitochondrial protein quality control systems in aging and disease. Adv Exp Med Biol. 2010;694:108-25. [Crossref] [PubMed]
  23. Turunen M, Olsson J, Dallner G. Metabolism and function of coenzyme Q. Biochim Biophys Acta. 2004;1660(1-2):171-99. [Crossref] [PubMed]
  24. Bentinger M, Brismar K, Dallner G. The antioxidant role of coenzyme Q. Mitochondrion. 2007;7 Suppl:S41-50. [Crossref] [PubMed]
  25. Ochiai A, Itagaki S, Kurokawa T, Kobayashi M, Hirano T, Iseki K. Improvement in intestinal coenzyme Q10 absorption by food intake. Yakugaku Zasshi. 2007;127(8):1251-4.[Crossref] [PubMed]
  26. Gosden RG. Oogenesis as a foundation for embryogenesis. Mol Cell Endocrinol. 2002;186(2):149-53. [Crossref]
  27. El Refaeey A, Selem A, Badawy A. Combined coenzyme Q10 and clomiphene citrate for ovulation induction in clomiphene-citrateresistant polycystic ovary syndrome. Reprod Biomed Online. 2014;29(1):119-24. [Crossref] [PubMed]