ABSTRACT
Objective: To evaluate the effects of intraoperative administration of tranexamic acid on perioperative and postoperative bleeding, the need for blood transfusion, the duration of the operation, and the length of hospital stay in patients undergoing myomectomy. Material and Methods: This case-control study involved 56 patients who underwent laparotomic myomectomy at our hospital between March 2023-January 2024. Intraoperatively, 28 patients who were administered tranexamic acid and 28 control groups who did not receive tranexamic acid were included in the study. Demographic characteristics, platelet count, prothrombin time, characteristics of fibroids, need for erythrocyte suspension (ES), and pre-postoperative hemoglobin values were compared between the groups. The criteria for administering ES are patients with a shock index above 1. Results: There was no statistically significant difference between the 2 groups in terms of demographic characteristics, platelet count, international normalized ratio, activated partial thromboplastin time test, and fibroid parameters (p>0.05). No statistically significant difference between postoperative 2nd and 6th hour hemoglobin values (p=0.225, p=0.159 respectively). No statistically significant difference between postoperative 2nd and 6th hour hematocrit values (p=0.225, p=0.178 respectively). ES transfusion was statistically significantly lower in the tranexamic acid group than in the control group (p=0.049). Conclusion: Tranexamic acid was effective in bleeding control by reducing the need for ES, but its antifibrinolytic effect was limited due to the low amount of bleeding. In the comparison between cases that did not receive ES transfusion and the control group, there was no statistically significant difference between the hemoglobin and hematocrit values. In the group of cases that did not undergo ES transfusion, the low amount of bleeding resulted in a low amount of fibrin, which limited the effect of tranexamic acid.