E-ISSN: 2619-9467

Contents    Cover    Publication Date: 11 Aug 2020
Year 2020 - Volume 30 - Issue 2

Open Access

Peer Reviewed

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Evaluation of the Relationship Between the Level of Vitamin D in Maternal Blood and Breast Milk and Postpartum Depression

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J Clin Obstet Gynecol. 2020;30(2):58-64
DOI: 10.5336/jcog.2020-74215
Article Language: EN
Copyright Ⓒ 2020 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Objective: This study aimed to evaluate the relationship between postpartum depression (PPD) and vitamin D levels in maternal blood and breast milk. Material and Methods: The study included women who presented to a polyclinic between December 2017 and August 2018, 4-6 weeks after having given live birth, who were aged between 18 and 40 years and married, gave birth after a planned single pregnancy, were feeding their baby with only breast milk and stated that they were taking vitamin D supplementation at the dose recommended by the Ministry of Health. The depression status of the women who agreed to participate in the study by signing the volunteer informed consent form was evaluated using the Edinburgh Postpartum Depression Scale (EPDS). Two groups were formed as Group 1: EPDS score <13 (n=44) (without PPD) and Group 2: EPDS score ≥13 (n=31) (with PPD). The vitamin D levels in breast milk and maternal blood in both groups were compared. Results: 75 female patients included in the study had a mean age of 29.80±4.54 years. The mean vitamin D levels in breast milk and maternal blood were found to be 13.26±5.39 ng/mL and 17.14±6.79 ng/mL, respectively. In terms of depression status, no statistically significant difference was found between the groups regarding the serum vitamin D levels and the mean level of vitamin D in breast milk (p=0.463, p=0.847). Conclusion: No significant correlation was determined between the vitamin D levels in maternal blood and breast milk and PPD, while vitamin D was found to be low both in maternal blood and breast milk.
  1. Kingston D, McDonald S, Austin M-P, Tough S. Association between prenatal and postnatal psychological distress and toddler cognitive development: a systematic review. PLoS One. 2015;21;10(5):e0126929. [Crossref]  [PubMed]  [PMC] 
  2. Villegas L, McKay K, Dennis C-L, Ross LE. Postpartum depression among rural women from developed and developing countries: a systematic review. J Rural Health. 2011;27(3):278-88. [Crossref]  [PubMed] 
  3. Zhang Y, Gong Y, Xue H, Xiong J, Cheng G. Vitamin D and gestational diabetes mellitus: a systematic review based on data free of Hawthorne effect. BJOG. 2018;125(7):784-93. [Crossref]  [PubMed] 
  4. Serrano-Díaz NC, Gamboa-Delgado EM, Domínguez-Urrego CL, Vesga-Varela AL, Serrano-Gómez SE, Quintero-Lesmes DC. [Vitamin D and risk of preeclampsia: a systematic review and meta-analysis]. Biomedica. 2018;1;38 Suppl 1:43-53. [Crossref]  [PubMed] 
  5. Anglin RES, Samaan Z, Walter SD, McDonald SD. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry. 2013;202:100-7. [Crossref]  [PubMed] 
  6. Parker GB, Brotchie H, Graham RK. Vitamin D and depression. J Affect Disord. 2017;15;208:56-61. [Crossref]  [PubMed] 
  7. McCann JC, Ames BN. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J. 2008;22(4):982-1001. [Crossref]  [PubMed] 
  8. Bivona G, Gambino CM, Iacolino G, Ciaccio M. Vitamin D and the nervous system. Neurol Res. 2019;41(9):827-35. [Crossref]  [PubMed] 
  9. Fernandes de Abreu DA, Eyles D, Feron F. Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology. 2009;34 Suppl 1:S265-77. [Crossref]  [PubMed] 
  10. Buell JS, Dawson-Hughes B. Vitamin D and neurocognitive dysfunction: preventing "D"ecline? Mol Aspects Med. 2008;29(6):415-22. [Crossref]  [PubMed]  [PMC] 
  11. DeLuca GC, Kimball SM, Kolasinski J, Ramagopalan SV, Ebers GC. Review: the role of vitamin D in nervous system health and disease. Neuropathol Appl Neurobiol. 2013;39(5):458-84. [Crossref]  [PubMed] 
  12. Nielsen NO, Strøm M, Boyd HA, Andersen EW, Wohlfahrt J, Lundqvist M, et al. Vitamin D status during pregnancy and the risk of subsequent postpartum depression: a case-control study. PLoS One. 2013;27;8(11):e80686. [Crossref]  [PubMed]  [PMC] 
  13. Trujillo J, Vieira MC, Lepsch J, Rebelo F, Poston L, Pasupathy D, et al. A systematic review of the associations between maternal nutritional biomarkers and depression and/or anxiety during pregnancy and postpartum. J Affect Disord. 2018;232:185-203. [Crossref]  [PubMed] 
  14. Aghajafari F, Letourneau N, Mahinpey N, Cosic N, Giesbrecht G. Vitamin D deficiency and antenatal and postpartum depression: a systematic review. Nutrients. 2018;10(4):478. [Crossref]  [PubMed]  [PMC] 
  15. Lukaszuk JM, Luebbers PE. 25(OH)D status: effect of D(3) supplement. Obes Sci Pract. 2017;3(1):99-105. [Crossref]  [PubMed]  [PMC] 
  16. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30. [Crossref]  [PubMed] 
  17. Gur EB, Gokduman A, Turan GA, Tatar S, Hepyilmaz I, Zengin EB, et al. Mid-pregnancy vitamin D levels and postpartum depression. Eur J Obstet Gynecol Reprod Biol. 2014;179:110-6. [Crossref]  [PubMed] 
  18. Cox JL, Holden JM, Sagovsky R. Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. Br J Psychiatry. 1987;150:782-6. [Crossref]  [PubMed] 
  19. Engindeniz AN, Küey L, Kültür S. Edinburgh Doğum Sonrası Depresyon Ölçeği Türkçe formu geçerlilik ve güvenilirlik çalışması. 1st ed. Ankara: Psikiyatri Derneği Yayınları. 1996. p.51-2.
  20. Hekimsoy Z, Dinç G, Kafesçiler S, Onur E, Güvenç Y, Pala T, et al. Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health. 2010;23;10:782. [Crossref]  [PubMed]  [PMC] 
  21. Halicioglu O, Aksit S, Koc F, Akman SA, Albudak E, Yaprak I, et al. Vitamin D deficiency in pregnant women and their neonates in spring time in western Turkey. Paediatr Perinat Epidemiol. 2012;26(1):53-60. [Crossref]  [PubMed] 
  22. Robinson M, Whitehouse AJ, Newnham JP, Gorman S, Jacoby P, Holt BJ, et al. Low maternal serum vitamin D during pregnancy and the risk for postpartum depression symptoms. Arch Womens Ment Health. 2014;17(3):213-9. [Crossref]  [PubMed] 
  23. Fu CW, Liu JT, Tu WJ, Yang JQ, Cao Y. Association between serum 25-hydroxyvitamin D levels measured 24 hours after delivery and postpartum depression. BJOG. 2015;122(12):1688-94. [Crossref]  [PubMed] 
  24. Accortt EE, Schetter CD, Peters RM, Cassidy-Bushrow AE. Lower prenatal vitamin D status and postpartum depressive symptomatology in African American women: Preliminary evidence for moderation by inflammatory cytokines. Arch Womens Ment Health. 2016;19(2):373-83. [Crossref]  [PubMed]  [PMC] 
  25. Gould JF, Anderson AJ, Yelland LN, Smithers LG, Skeaff CM, Gibson RA, et al. Association of cord blood vitamin D at delivery with postpartum depression in Australian women. Aust N Z J Obstet Gynaecol. 2015;55(5):446-52. [Crossref]  [PubMed] 
  26. Weisman Y, Bawnik JC, Eisenberg Z, Spirer Z. Vitamin D metabolites in human milk. J Pediatr. 1982;100(5):745-8. [Crossref]  [PubMed] 
  27. Specker BL, Tsang RC, Hollis BW. Effect of race and diet on human-milk vitamin D and 25-hydroxyvitamin D. Am J Dis Child. 1985;139(11):1134-7. [Crossref]  [PubMed] 
  28. Bae YJ, Kratzsch J. Vitamin D and calcium in the human breast milk. Best Pract Res Clin Endocrinol Metab. 2018;32(1):39-45. [Crossref]  [PubMed] 
  29. Holick MF. Resurrection of vitamin D deficiency and rickets. J Clin Invest. 2006;116(8):2062-72. [Crossref]  [PubMed]  [PMC] 
  30. WHO. Global Strategy on Infant and Young Child Feeding. Geneva: World Health Organization; 2003. p.30.
  31. Thiele DK, Senti JL, Anderson CM. Maternal vitamin D supplementation to meet the needs of the breastfed infant: a systematic review. J Hum Lact. 2013;29(2):163-70. [Crossref]  [PubMed] 
  32. Hatun S, Ozkan B, Bereket A. Vitamin D deficiency and prevention: Turkish experience. Acta Paediatr. 2011;100(9):1195-9. [Crossref]  [PubMed] 
  33. Grady LT, Thakker KD. Stability of solid drugs: degradation of ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3) at high humidities and elevated temperatures. J Pharm Sci. 1980;69(9):1099-102. [Crossref]  [PubMed] 
  34. Blanco D, Fernandez MP, Gutierrez MD. Simultaneous determination of fat-soluble vitamins and provitamins in dairy products by liquid chromatography with a narrow-bore column. Analyst. 2000;125(3):427-31. [Crossref]  [PubMed] 
  35. Kull Jr M, Kallikorm R, Tamm A, Lember M. Seasonal variance of 25-(OH) vitamin D in the general population of Estonia, a Northern European country. BMC Public Health. 2009;19;9:22. [Crossref]  [PubMed]  [PMC]