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Pregnancy Outcome in aRenal Transplant Recipient Treated with Tacrolimus
Gebeli̇ği̇nde Tacroli̇mus Alan Renal Transplantli Anne Bebeği̇
Münevver TÜRKMEN*, Ayşe TOSUN**, Ali Rıza ODABAŞI***, Ferah SÖNMEZ****, Alper BIÇKICI*****, Gülten İNAN******
* Neonatolog, Neonatal Intensive Care Unit, Department of Pediatrics, Adnan Menderes University Faculty of Medicine**, Department of Pediatrics, Adnan Menderes University Faculty of Medicine***, Department of Gynecology and Obstetrics, Adnan Menderes University Faculty of Medicine****, Department of Pediatric Nephrology, Adnan Menderes University Faculty of Medicine*****, Research Assis., Department of Pediatrics, Adnan Menderes University Faculty of Medicine******, Department of Pediatrics, Adnan Menderes University Faculty of Medicine, Aydın, TURKEY
Turkiye Klinikleri J Gynecol Obst. 2003;13(2):138-40
Article Language: TR
Copyright Ⓒ 2024 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (
http://creativecommons.org/licenses/by-nc-nd/4.0/)
ÖZET
Amaç: Bu yazıda, gebeliğinde takrolimus ve azatiopürin tedavisi alan renal transplantlı bir annenin bebeği sunulmaktadır.Çalışmanın Yapıldığı Yer: Adnan Menderes Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum AD, Çocuk Sağlığı ve Hastalıkları AD, Yenidoğan Yoğun Bakım Ünitesi, Aydın.Materyal ve Metod: Erken, membran rüptürü ve fetal distress nedeniyle acil seksiyo-sezaryenle 29.gebelik haftasında doğurtulan erkek bebeğin, birinci ve beşinci dakika Apgar skorları sırasıyla 7 ve 8 idi. Doğum ağırlığı 1180 gr. (25-50 persantil), baş çevresi 26 cm. (10?25 persantil) ve boyu 36 cm. (25?50 persantil) ölçüldü. Bebeğin laboratuvar tetkiklerinde; kan biyokimyası, postnatal ilk gün ortaya çıkan, iki gün devam eden hiperpotasemisi dışında normal sınırlardaydı. Ekokardiogramı, abdominal ve kraniyal ultrasonografik incelemeleri normal bulundu. Klinik izleminde, yaşamın ilk günlerinde gelişen, prematürite oluşundan kaynaklanan apneleri aminofilin tedavisine cevap verdi. İlk 24 saat de 6,4 mg/dlye ulaşan total bilirübin düzeyi nedeniyle, olguya iki gün süreyle fototerapi uygulandı. Doğum sonrası 50.günde olgu sağlıklı olarak taburcu edildi. Sonuç: Bir olguyla, böbrek nakli yapılmış ve gebeliğinde tacrolimus tedavisi alan annelerin de, sağlıklı çocuk sahibi olabileceklerine ait mevcut bilgilere katkıda bulunmak istedik.
ABSTRACT
Objective: We report here the outcome of a pregnancy in a woman with renal transplant maintained on tacrolimus and azathioprine.Instution: Neonatal Intensive Care Unit, Department of Pediatrics and Department of Gynecology and Obstetrics, Adnan Menderes University Faculty of Medicine, Turkey.Materials and Methods: The male baby was delivered at a gestational age of 29 weeks, by emergency Cesarean section due to fetal distress and preterm premature rupture of membranes. Apgar scores were 7 and 8 at 1 and 5 minutes, respectively. His birth weight was 1180 g. (25-50 percentile), head circumference was 26 cm. (10-25 percentile), and length was 36 cm. (25-50 percentile). His routine blood tests were all within the normal range, except a transient hyperkalemia detected on the first postnatal day and controlled two days later. He had a transient hyperkalemia on the first postnatal day. The echocardiogram, abdominal and cranial sonography were normal.He also initially developed apnea and was treated with aminophylline that was tapered off on the postnatal 43rd day. He required two-day phototherapy for increased for total bilirubin level (6.4 mg/dl) at the first day. He was discharged on 50th day.Conclusion: The woman had kidney transplantation and received tacrolimus treatment during pregnancy and gave birth to healty child. We would like to contribute to the avaiblable knowledge and experience in such conditions with our one case.