ÖZET
Prematür ovaryan yetmezlikli 10 hasta çalışmaya alındı. Bunlardan 6'sının ailesinin en az bir bireyinde amenore veya idiopatik ovaryan yetmezlik vardı. Geri kalan 4 hastanın birinin kız kardeşinde meme kanseri, erkek kardeşinde de diabetes mellitus vardı. Bu hastalarda antiovaryan antikor bakıldı, beyaz küre, lenfosit, B ve BT lenfosit sayımı yapıldı. Ailesinde meme kanseri ve diabetes mellitus olan hastada otoantikor dağılımı ölçüldü. Hastaların yakın akrabalarında da antiovaryan antikor bulundu. İki hastada antiovaryan antikor pozitif bulundu (%20). Ailesinde meme kanseri ve diabet olan hastada antinükleer antikor ve pozitifti (%10). Antiovaryan antikor pozitif olan iki hastanın yakın akrabalarında da pozitif bulundu. Otoantikoru yüksek olan hastalarda orta derecede yüksek B lenfosit, hafif derecede de yüksek beyaz küre, lenfosit ve T lenfosit saptandı.

ABSTRACT
10 patients with premature ovarian failure were studied. Among the families of 6 of these, at least one member in each family was found to have had amenorrhoea or idiopathic premature ovarian failure. Among the remaining 4 patients one had a sister who had breast cancer and a brother suffering from diabetes mellitus. These patients were tested for antiovarian antibody, counts of white blood cells (WBC). Lymphocytes, B cells and T celles. The patient with a family history of breast cancer and diabetes mellitus was tested for a range of autoantibodies. Next of kin of the patients were also tested for antiovarian antibody. 2 of the patients were positive for antiovarian antibody (20%). The patient with a family history of breast cancer and diabetes mellitus was positive for antinuclear antibody (10%). Also the next of kin of two antibody positive for patients were found positive for antiovarian antibody. Patients with autoantibodies had moderately higher B cell counts, but slightly elevated WBC, lymphocyte and T cell counts.