E-ISSN: 2619-9467

Contents    Cover    Publication Date: 28 Mar 2019
Year 2019 - Volume 29 - Issue 1

Open Access

Peer Reviewed

CASE REPORTS
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Importance of Cuff Cytology and Human Papillomavirus Screening, Especially in Patients with Autoimmune Disorders

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J Clin Obstet Gynecol. 2019;29(1):39-42
DOI: 10.5336/jcog.2019-65338
Article Language: EN
Copyright Ⓒ 2024 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
This article aims to report the results of four cases of human papillomavirus (HPV) positivity and abnormal cuff smear. A hysterectomy was performed in this study to eliminate precancerous cervical lesion in one patient and uterine myoma in another. Subsequent follow-up of the patients revealed HPV DNA positivity in cuff cytology, even though both the patients tested negative for HPV prior to hysterectomy. Cuff cytology and HPV DNA screening, therefore, seem to be important in dicey and benign cases, especially occurring together with autoimmune disorders. HPV type 16 was found to be the most frequent subtype (75%) in this study.
REFERENCES:
  1. Videlefsky A, Grossl N, Denniston M, Sehgal R, Lane JM, Goodenough G. Routine vaginal cuff smear testing in post-hysterectomy pa- tients with benign uterine conditions: when is it indicated? J Am Board Fam Pract. 2000;13(4):233-8. [Crossref]  [PubMed]
  2. Neis KJ,  Zubke W, Fehr  M, Römer T, Tamussino K, Nothacker  M. Hysterectomy for benign uterine disease.  Dtsch Arztebl Int. 2016;113(14):242-9. [Crossref]
  3. Bansal M, Austin RM, Zhao C. Correlation of histopathologic follow-up findings with vaginal human papillomavirus and low-grade squa- mous intraepithelial lesion Papanicolaou test results. Arch Pathol Lab Med. 2011;135(12):1545-9. [Crossref]  [PubMed]
  4. Rajaram S,  Maheshwari A, Srivastava  A. Staging for vaginal  cancer. Best Pract  Res Clin Obstet Gynaecol.  2015;29(6):822-32. [Crossref]  [PubMed]
  5. Aho M, Vesterinen E, Meyer B, Purola E, Paavonen J. Natural history of vaginal in- traepithelial neoplasia. Cancer. 1991;68(1): 195-7. [Crossref]
  6. Frega A, French D, Piazze J, Cerekja A, Ve- trano G, Moscarini M. Prediction of persistent vaginal intraepithelial neoplasia in previously hysterectomized women by high-risk HPV DNA detection. Cancer Lett.  2007;249(2):235- 41. [Crossref]  [PubMed]
  7. So KA, Hong JH, Hwang JH, Song SH, Lee JK, Lee NW, et al. The utility of the human pa pillomavirus DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia. J Gynecol Oncol. 2009;20(4):232-17 [Crossref]  [PubMed]  [PMC]
  8. Committee on Practice Bulletins-Gynecol- ogy. Practice Bulletin No. 168: Cervical Can- cer Screening   and Prevention.   Obstet Gynecol. 2016;128(4):e111-30. [Crossref]   [PubMed]
  9. Khan MJ, Massad LS, Kinney W, Gold MA, Mayeaux EJ Jr, Darragh TM, et al. A com- mon clinical  dilemma: management of ab- normal vaginal cytology  and human papillomavirus test results. Gynecol Oncol. 2016;141(2):364-70. [Crossref]  [PubMed]  [PMC]
  10. Schockaert S,  Poppe W, Arbyn  M, Verguts T, Verguts J. Incidence  of vaginal intraepithelial neoplasia after hysterectomy  for cervical  in- traepithelial neoplasia: a  retrospective study. Am J  Obstet Gynecol. 2008;199(2):113.e1-5.  [Crossref]  [PubMed]
  11. Castle PE,  Rodriguez AC, Porras  C, Herrero R, Schiffman M,  Gonzalez P, et  al. A compar- ison of cervical  and vaginal human  papillo- mavirus. Sex Transm  Dis. 2007;34(11): 849-55. [Crossref]  [PubMed]  [PMC]
  12. Liu X, Yue Y, Zong S. Post-hysterectomy vaginal  cuff cancer   secondary  to HPV infection  and CIN: a case  report. Pak J Med Sci.  2013;29(4):1068-70. [PubMed]  [PMC]
  13. Öz ZS, Demirezen Ş, Kuzey GM, Beksaç MS, Ustaçelebi Ş. Cytologic and clinical eval- uation of human papillomavirus in women un- derwent routine gynecologic examination. Gynecology Obstetrics & Reproductive Medi- cine. 2009;15(2).
  14. D?Souza G, Westra WH, Wang SJ, van Zante A, Wentz A, Kluz N, et al. Differences in the prevalence of human papillomavirus (HPV) in head and neck squamous cell cancers by sex, race, anatomic tumor site, and HPV detection method. JAMA Oncol. 2017;3(2):169-77. [Crossref]  [PubMed]
  15. Wakeham K, Kavanagh K. The burden of HPV-associated anogenital cancers. Curr Oncol Rep. 2014;16(9):402. [Crossref]   [PubMed]
  16. Burd EM. Human papillomavirus and cervical cancer. Clin Microbiol Rev 2003;16(1):1-17. [Crossref]  [PubMed]  [PMC]
  17. Castle PE, Schiffman M, Bratti MC, Hildesheim A, Herrero R, Hutchinson ML, et al. A population-based study of vaginal human papillomavirus infection in hysterectomized women. J Infect Dis. 2004;190(3):458-67.  [Crossref]  [PubMed]
  18. Santana IU, do Nascimento Gomes A, Lyrio LDC, Grassi MFR, Santiago MB. Systemic lupus erythematosus, human papillomavirus infection, cervical pre-malignant and malignant lesions: a systematic review. Clin Rheumatol. 2011;30(5):665-72. [Crossref]  [PubMed]
  19. Tam LS,  Chan PK, Ho  SC, Yu MM,  Yim SF, Cheung TH, et  al. Natural history  of cervical papilloma virus  infection in systemic  lupus ery- thematosus-a prospective  cohort study. J Rheumatol. 2010;37(2):330-40. [Crossref]  [PubMed]
  20. Rojo-Contreras W, Olivas-Flores EM, Gamez- Nava JI, Montoya-Fuentes H, Trujillo-Hernan- dez B, Trujillo X, et al. Cervical human papillomavirus infection in Mexican women with systemic lupus erythematosus or rheuma- toid arthritis. Lupus. 2012;21(4):365-72. [Crossref]  [PubMed]
  21. Raposo A,  Tani C, Costa  J, Mosca M.  Human papillomavirus infection and  cervical lesions in rheumatic  diseases: a systematic  review. Acta Reumatol Port.  2016;41(3):184-90.[PubMed]