ABSTRACT
This article documents a case of isolated eosinophilic myometritis (IEM) in a peri-menopausal woman presenting with abnormal uterine bleeding with a brief review of the literature. A 48-year-old peri-menopausal woman presented to the gynecology department with easy fatigability, abdominal pain radiating to the back of the leg, irregular cycles, dysmenorrhea, and menorrhagia for the last three months. The present case describes the histopathological findings of an IEM, without any kind of endometrial involvement or pathology in a perimenopausal woman lacking a history of previous invasive procedure or intervention, allergic manifestation, or systemic disorder. IEM is a cause of abnormal uterine bleeding, which usually represents repair/regeneration-associated changes. Larger case studies are needed to explore the significance of eosinophils in myometrial inflammation or repair and to determine their role in IEM and other non-neoplastic lesions and the contribution of the individual subpopulations of eosinophils.