E-ISSN: 2619-9467

Contents    Cover    Publication Date: 19 Apr 2024
Year 2024 - Volume 34 - Issue 1

Open Access

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Isolated Eosinophilic Myometritis-A Rare Cause of Abnormal Uterine Bleeding in a Peri-menopausal Woman with Review of the Literature

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JCOG. 2024;34(1):41-6
DOI: 10.5336/jcog.2023-98463
Article Language: EN
Copyright Ⓒ 2020 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
This article documents a case of isolated eosinophilic myometritis (IEM) in a peri-menopausal woman presenting with abnormal uterine bleeding with a brief review of the literature. A 48-year-old peri-menopausal woman presented to the gynecology department with easy fatigability, abdominal pain radiating to the back of the leg, irregular cycles, dysmenorrhea, and menorrhagia for the last three months. The present case describes the histopathological findings of an IEM, without any kind of endometrial involvement or pathology in a perimenopausal woman lacking a history of previous invasive procedure or intervention, allergic manifestation, or systemic disorder. IEM is a cause of abnormal uterine bleeding, which usually represents repair/regeneration-associated changes. Larger case studies are needed to explore the significance of eosinophils in myometrial inflammation or repair and to determine their role in IEM and other non-neoplastic lesions and the contribution of the individual subpopulations of eosinophils.
  1. Bjersing L, Borglin NE. Eosinophilia in the myometrium of the hu-man uterus. Acta Pathol Microbiol Scand. 1962;54:353-64. [PubMed] 
  2. Mohammad G, Rustom F, Albinsson S, Wennerås C, Akyürek LM. Isolated eosinophilic myometritis: a case report of an extremely rare phenomenon. Int J Gynecol Pathol. 2022;41(3):e3-e7. [Crossref]  [PubMed] 
  3. Nandan G, Bal MS, Sharma A, Gupta N. Isolated eosinophilic myometritis-A rare histological finding. J Diagn Pathol Oncol. 2019;4(3):230-2. [Crossref] 
  4. Park YM, Bochner BS. Eosinophil survival and apoptosis in health and disease. Allergy Asthma Immunol Res. 2010;2(2):87-101. [Crossref]  [PubMed]  [PMC] 
  5. Kovalszki A, Weller PF. Eosinophilia. Prim Care. 2016;43(4):607-17. [Crossref]  [PubMed]  [PMC] 
  6. Spencer LA, Bonjour K, Melo RC, Weller PF. Eosinophil secretion of granule-derived cytokines. Front Immunol. 2014;5:496. [Crossref]  [PubMed]  [PMC] 
  7. Ueki S, Tokunaga T, Melo RCN, Saito H, Honda K, Fukuchi M, et al. Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death. Blood. 2018;132(20):2183-7. [Crossref]  [PubMed]  [PMC] 
  8. Divack DM, Janovski NA. D Eosinophilia encountered in female genital organs. Amer Jr Obst Gynaec. 1962;84(6):761-3. [Crossref]  [PubMed] 
  9. Kato M, Kephart GM, Morikawa A, Gleich GJ. Eosinophil infiltration and degranulation in normal human tissues: evidence for eosinophil degranulation in normal gastrointestinal tract. Int Arch Allergy Immunol. 2001;125 Suppl 1:55-8. [Crossref]  [PubMed] 
  10. Wechsler ME, Munitz A, Ackerman SJ, Drake MG, Jackson DJ, Wardlaw AJ, et al. Eosinophils in health and disease: a state-of-the-art review. Mayo Clin Proc. 2021;96(10):2694-707. [Crossref]  [PubMed] 
  11. Valent P, Klion AD, Horny HP, Roufosse F, Gotlib J, Weller PF, et al. Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. J Allergy Clin Immunol. 2012;130(3):607-12.e9. [Crossref]  [PubMed]  [PMC] 
  12. Lowe D, Jorizzo J, Hutt MS. Tumour-associated eosinophilia: a review. J Clin Pathol. 1981;34(12):1343-8. [Crossref]  [PubMed]  [PMC] 
  13. Saraiva AL, Carneiro F. New insights into the role of tissue eosinophils in the progression of colorectal cancer: a literature review. Acta Med Port. 2018;31(6):329-37. [Crossref]  [PubMed] 
  14. Mascitti M, Togni L, Rubini C, Troiano G, Lo Muzio L, Santarelli A. Tumour-associated tissue eosinophilia (TATE) in oral squamous cell carcinoma: a comprehensive review. Histol Histopathol. 2021;36(2):113-22. [PubMed] 
  15. Hu G, Wang S, Zhong K, Xu F, Huang L, Chen W, et al. Tumor-associated tissue eosinophilia predicts favorable clinical outcome in solid tumors: a meta-analysis. BMC Cancer. 2020;20(1):454. [Crossref]  [PubMed]  [PMC]