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Reversal of Propylthiouracil Induced-Fetal Ascites in Monochorionic Twins
Received: 07 Nov 2020 | Accepted: 19 Jan 2021 | Available online: 08 Feb 2021
J Clin Obstet Gynecol. 2021;31(1):28-30
DOI: 10.5336/jcog.2020-79962
Article Language: EN
Article Language: EN
Copyright Ⓒ 2024 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
There are various causes in the etiology of fetal ascites and non-immune hydrops fetalis. Pathogenesis of non-immune hydrops fetalis is incompletely understood. The etiology cannot be determined in yet a large part of cases. Here we reported an isolated fetal ascites case in both fetuses, in a monochorionic pregnancy during maternal propylthiouracil (PTU) use. Fetal goiter was detected in both fetuses and after maternal oral tri-iodothyronine treatment, ascites resolved and babies were delivered at 36th week of pregnancy. Anti-thyroid drugs (ATDs) should be used carefully during pregnancy. Fetal hypothyroidism may be associated with fetal hyrdrops. Maternal oral tri-iodothyronine administration may treat fetal hypothyroidism.
There are various causes in the etiology of fetal ascites and non-immune hydrops fetalis. Pathogenesis of non-immune hydrops fetalis is incompletely understood. The etiology cannot be determined in yet a large part of cases. Here we reported an isolated fetal ascites case in both fetuses, in a monochorionic pregnancy during maternal propylthiouracil (PTU) use. Fetal goiter was detected in both fetuses and after maternal oral tri-iodothyronine treatment, ascites resolved and babies were delivered at 36th week of pregnancy. Anti-thyroid drugs (ATDs) should be used carefully during pregnancy. Fetal hypothyroidism may be associated with fetal hyrdrops. Maternal oral tri-iodothyronine administration may treat fetal hypothyroidism.
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