E-ISSN: 2619-9467

Contents    Cover    Publication Date: 20 Sep 2023
Year 2023 - Volume 33 - Issue 3

Open Access

Peer Reviewed

ORIGINAL RESEARCH
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Second Trimester Fetal Nasal Bone Length Measurement: A Single Center Study and National Data Review

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JCOG. 2023;33(3):184-90
DOI: 10.5336/jcog.2023-95648
Article Language: EN
Copyright Ⓒ 2024 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
Objective: To evaluate second trimester fetal nasal length measurement results in healthy singleton pregnancies in Turkey. Material and Methods: We analyzed the nasal bone lengths within 19-24 weeks in 661 pregnancies in our hospital. All pregnant women with a single healthy fetus who applied to our perinatology outpatient clinic for detailed obstetric ultrasonography were included in the study. All measurements were performed by the same clinician during routine mid-trimester ultrasound scan. Only the patients who were considered healthy by the examining pediatrician were included in the study. The parents of all fetuses are of Turkish ethnicity. Pearson correlation, regression analysis and P value were calculated between gestational week and nasal bone length. Results: Mean nasal length measurement was 6,21 ± 0,08; 6,66 ± 0,05; 6,88 ±0,05; 7,13 ± 0,08; 7,77 ± 0,11 and 8,33 ± 0,25 mm from 19 to 24 week of pregnancy, respectively. A significant positive correlation was observed between gestational week and nasal bone length. Normal values of nasal bone length measuremens are identified for each gestational weeks acoording to our data and previous 5 studies. Conclusion: In this study, we presented the data of our own center and the results obtained from other studies conducted in our country show significant differences. We are of the opinion that studies conducted by different researchers in different regions remain insufficient to reflect the nomogram of Turkish ethnic origin. For this purpose, multicenter studies are needed to cover the whole society.
REFERENCES:
  1. Salomon LJ, Alfirevic Z, Berghella V, Bilardo CM, Chalouhi GE, Da Silva Costa F, et al. ISUOG Practice Guidelines (updated): performance of the routine mid-trimester fetal ultrasound scan. Ultrasound Obstet Gynecol. 2022;59(6):840-56. Erratum in: Ultrasound Obstet Gynecol. 2022;60(4):591. [Crossref]  [PubMed] 
  2. Keeling JW, Hansen BF, Kjaer I. Pattern of malformations in the axial skeleton in human trisomy 21 fetuses. Am J Med Genet. 1997;68(4):466-71. [Crossref]  [PubMed] 
  3. Stempfle N, Huten Y, Fredouille C, Brisse H, Nessmann C. Skeletal abnormalities in fetuses with Down's syndrome: a radiographic post-mortem study. Pediatr Radiol. 1999;29(9):682-8. [Crossref]  [PubMed] 
  4. T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü Kadın ve Üreme Sağlığı Dairesi Başkanlığı. Doğum Öncesi Bakım Yönetim Rehberi. Ankara: Sağlık Bakanlığı Yayın; 2018. [Link] 
  5. Yayla M, Goynumer G, Uysal O. Fetal nasal bone length nomogram. Perinat J. 2006;14(2):77-82. [Link] 
  6. Özdemirci Ş, Esinler D, Özdemirci F, Bilge M, Akpınar F, Kahyaoğlu İ. Assessment of nuchal translucency nasal bone and ductus venosus flow in the first trimester: pregnancy outcomes. Gynecology Obstetrics & Reproductive Medicine. 2014;20(2):73-6. [Link] 
  7. Bernardeco J, Cruz J, Rijo C, Cohen Á. Nasal bone in fetal aneuploidy risk assessment: are they independent markers in the first and second trimesters? J Perinat Med. 2022;50(4):462-6. [Crossref]  [PubMed] 
  8. Moczulska H, Serafin M, Wojda K, Borowiec M, Sieroszewski P. Fetal nasal bone hypoplasia in the second trimester as a marker of multiple genetic syndromes. J Clin Med. 2022;11(6):1513. [Crossref]  [PubMed]  [PMC] 
  9. Küpeli A, Ahmetoğlu A, Güvendağ Güven ES, Cansu A, Süleyman Ş, Dinç H. 18+0-23+6. gebelik haftalarında fetal nazal kemik uzunluğunun değerlendirilmesi [Evaluation of fetal nasal bone length during 18+0-23+6 gestational weeks]. Ortadogu Tıp Derg. 2019;11(4):461-7. [Crossref] 
  10. Goynumer G, Arisoy R, Yayla M, Erdogdu E, Ergin N. Fetal nasal bone length during the second trimester of pregnancy in a Turkish population. Eur J Obstet Gynecol Reprod Biol. 2014;176:96-8. Erratum in: Eur J Obstet Gynecol Reprod Biol. 2014;182:264. [Crossref]  [PubMed] 
  11. Asal N, Dizen P, Kaçar M, Yılmaz Ö, Ünlü E, Köse S, et al. İkinci trimester gebeliklerde fetal nazal kemik uzunluğunun değerlendirilmesi [Fetal nasal bone length evaluation in second trimester pregnancies]. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2013;4(3):111-6. [Link] 
  12. Yalınkaya A, Güzel A, Uysal E, Kangal K, Kaya Z. Gebelik haftalarına göre fetal nazal kemik uzunluğu nomogramı [The fetal nose bone nomogram according to gestational weeks]. Perinatoloji Dergisi. 2009;17(3):100-3. [Link] 
  13. Kavak SB, Kavak EC. Assessment of the nasal bone by 2-dimensional ultrasound in 2 different planes: do they give the same results? J Ultrasound Med. 2020;39(4):659-64. [Crossref]  [PubMed] 
  14. Odibo AO, Sehdev HM, Dunn L, McDonald R, Macones GA. The association between fetal nasal bone hypoplasia and aneuploidy. Obstet Gynecol. 2004;104(6):1229-33. [Crossref]  [PubMed] 
  15. Guis F, Ville Y, Vincent Y, Doumerc S, Pons JC, Frydman R. Ultrasound evaluation of the length of the fetal nasal bones throughout gestation. Ultrasound Obstet Gynecol. 1995;5(5):304-7. [Crossref]  [PubMed] 
  16. Zelop CM, Milewski E, Brault K, Benn P, Borgida AF, Egan JF. Variation of fetal nasal bone length in second-trimester fetuses according to race and ethnicity. J Ultrasound Med. 2005;24(11):1487-9. [Crossref]  [PubMed] 
  17. Kanagawa T, Fukuda H, Kinugasa Y, Son M, Shimoya K, Murata Y, et al. Mid-second trimester measurement of fetal nasal bone length in the Japanese population. J Obstet Gynaecol Res. 2006;32(4):403-7. [Crossref]  [PubMed] 
  18. Chiu WH, Tung TH, Chen YS, Wang WH, Lee SM, Horng SC, et al. Normative curves of fetal nasal bone length for the ethnic Chinese population. Ir J Med Sci. 2011;180(1):73-7. [Crossref]  [PubMed] 
  19. Gautier M, Gueneret M, Plavonil C, Jolivet E, Schaub B. Normal range of fetal nasal bone length during the second trimester in an afro-caribbean population and likelihood ratio for trisomy 21 of absent or hypoplastic nasal bone. Fetal Diagn Ther. 2017;42(2):130-6. [Crossref]  [PubMed] 
  20. Araujo Júnior E, Martins WP, Pires CR, Moron AF, Zanforlin Filho SM. Reference range of fetal nasal bone length between 18 and 24 weeks of pregnancy in an unselected Brazilian population: experience from a single service. J Matern Fetal Neonatal Med. 2014;27(12):1276-9. [Crossref]  [PubMed] 
  21. Agathokleous M, Chaveeva P, Poon LC, Kosinski P, Nicolaides KH. Meta-analysis of second-trimester markers for trisomy 21. Ultrasound Obstet Gynecol. 2013;41(3):247-61. [Crossref]  [PubMed] 
  22. Prabhu M, Kuller JA, Biggio JR, Medicine SfM-F. Society for maternal-fetal medicine (SMFM) Consult Series# 57: evaluation and management of isolated soft ultrasound markers for aneuploidy in the second trimester. Am J Obstet Gynecol. 2021;225(4): B2-B15. [Crossref]  [PubMed]