Özge AKDENİZa, Nadiye KÖROĞLUa, Gonca YETKİN YILDIRIMa, Berna ASLAN ÇETİNa, İbrahim POLATa aDepartment of Obstetrics and Gynecology, Health Sciences University Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, TURKEY
ABSTRACT Objective: To investigate the relationship between reproductive outcomes and noncavity-distorting uterine myomas in women with unexplained infertility and undergoing ovulation induction and intrauterine insemination (OI-IUI). Material and Methods: Women between 18-40 years of age with regular ovulatory cycles and bilateral tubal patency as detected on hysterosalpingography (HSG) and with spouses having total progressive motile sperm (TPMSS) counts >5 million on spermiogram analysis, were included in this study. The number of women with noncavity-distorting myomas, as detected using ultrasonography, were recorded. The frequencies of pregnancies after OI-IUI, ectopic pregnancies, abortions, clinical pregnancies, and live births were compared between women with non-cavity-distorting myomas and those without myomas. Results: A total of 857 cycles of OI-IUI were administered to 436 patients, resulting in 110 pregnancies. Non-cavity-distorting myomas were recorded in 27 subjects. Using multivariate logistic regression analysis, the presence of non-cavity-distorting myoma significantly affected pregnancy (p<0.05). Conception (p=0.008), clinical pregnancy (p=0.034), and live birth rates (p=0.037) were significantly higher in patients without fibroids than those with fibroids. Conclusion: Conception, clinical pregnancy, and live birth rates were significantly higher in patients without uterine fibroids than those with fibroids. These findings suggest that myomas might have negative effects on fertility outcomes.