ABSTRACT
Objective: We aimed to evaluate alterations in expression of the genes, which are known to have a role in neuronal migration by the administration of daily life exposure doses of radiofrequency to pregnant mice. Material and Methods: Two groups were established. Each of them contained 6 female, 2 male Balb/c mice. They were weighted 15-20 g. For the occurrence of pregnancy, male and female mice were placed in cages mixed. The study and control groups were exposed to the radiofrequency field with the average specific absorption rate value of 0.725 W/kg, 12 hours a day until birth. Total RNA and cDNA were obtained from postnatal brain tissue of newborn mice. Alterations in the expression of 7 (ARX, FLNA, DCX, LARGE, RELN, TUBA1, YWHA) genes that are known to have a role in neuronal migration were investigated by real-time polymerase chain reaction. Results: The expressions of 6 of the 7 genes were found to be significantly increased. These genes were ARX, FLNA, DCX, LARGE, RELN and YWHAE. This study proved that even at low levels, magnetic field may affect the development of foetuses as a consequence of gene expression changes. Conclusion: Magnetic field may affect foetusess during pregnancy and precautions must be taken to prevent exposure.