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Can Rectal Indomethacin Be an Alternative Local Anesthetic Method to Intrauterine Lidocaine During Endometrial Biopsy? A Clinical Observational Prospective Study
Received: 16 Jan 2020 | Received in revised form: 16 Apr 2020
Accepted: 17 Apr 2020 | Available online: 20 Apr 2020Sinem DEMİRCAN KARADAĞa, Cihan KARADAĞb, Mehmet Baki ŞENTÜRKa, Abdülkadir TURGUTa
aİstanbul Medeniyet University Göztepe Training and Research Hospital, Department of Obstetrics and Gynecology, İstanbul, TURKEY
bİstanbul Okan University Faculty of Medicine, Department of Obstetrics and Gynecology, İstanbul, TURKEY
J Clin Obstet Gynecol. 2020;30(1):14-9
DOI: 10.5336/jcog.2020-73612
Article Language: EN
Copyright Ⓒ 2024 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (
http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
Objective: Endometrial biopsy is a pain-related gynecological procedure. The aim of this study is to compare the efficacy of rectal indomethacin and intrauterine lidocaine on pain control during endometrial sampling. Material and Methods: This clinical observational prospective trial was conducted in 120 patients with the complaint of abnormal uterine bleeding who presented at İstanbul Medeniyet University Göztepe Training and Research Hospital, Obstetrics and Gynecology Department, between January 2017 and June 2017. Patients were divided into two groups. The rectal group had 64 patients, to whom indomethacin was given as a local anesthetic. The intrauterine group had 56 patients, for whom lidocaine was the local anesthetic used. Endometrial biopsy was performed by using a no. 4 Karman cannula. The primary goal of measurement was pain intensity assessed by a visual analog scale before, during, and 10 minutes after the procedure. Results: There were no statistically significant differences between the two groups in mean age, body mass index, weight and median levels of gravidity, parity and abortion. The median pain scores of the two groups during and 10 minutes after the procedure were similar (p > 0.05). Conclusion: In this study, rectal indomethacin was shown to be equal to intrauterine anesthesia for reducing pain during the endometrial biopsy. Rectal indomethacin may be an alternative drug to relieve pain during gynecological procedures. Further researches with larger numbers of patients are needed to confirm our findings.
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